IMBS标志

Intestinal Metabolic Bromhidrosis Syndrome Alliance

赞助商

当有气味的肠道代谢物穿过肠壁屏障和肝脏时,它们会通过汗液和呼吸排出体外。由此产生的症状被称为臭汗症和口臭。

病人须知
Eurordis成员标志

语言。 BG | ZH | ZH-CN | ZH-TW | CS | CS-CZ | NL | NL-NL | EN | EN-AU | EN-CA | EN-IE | EN-GB | EN-US | FI-FI | FR | FR-FR | FR-CH | DE | DE-DE | EL-GR | IT-IT | JA | JA-JP | PL-PL | PT | PT-BR | RU | RU-RU | ES | ES-AR | ES-MX | ES-PE | ES-ES | ES-US | ES-XL | SV-SE |

)

不要让我们独自完成这项工作!不要被动--行动起来!和我们一起行动吧!

我们是像你这样的人,在各条战线上工作,使这种疾病得到承认,在医学上得到确立,并得到解决!这就是我们的目标。

与我们联手,用你能支持我们的一切来支持我们!

告诉你能想到的每一个人,关于这篇文字,关于这个团体,关于我们的目标!告诉他们加入。告诉他们加入!

没有人因此而得到钱,但也许我们都能找回我们的生活,我们的社会生活,我们的工作生活,所有的一切!"。

到处分享我们社区的链接,把人们聚集在一起--加入我们的联盟,成为与我们并肩作战的成员!

不要犹豫,不要独自奔跑,支持我们,得到我们的支持!

不要被动--行动起来!

与我们一起行动吧!

RareConnect

由于我们没有自己的论坛,我们参考了多语种的RareConnect论坛,那里的帖子被翻译成多种语言。

RareConnect 是由 EURORDIS .

RareConnect论坛是按罕见病社区分组的。在目前的时间点上,有两个小组可供选择。

论坛

讨论区服务器

为了协调研究、电子邮件活动和一般讨论,有一个供IMBS社区使用的discord服务器。

迪斯科服务器提供了一个有实时聊天、音频和视频频道的地方。( Discord主页 )

你可以通过discord安卓或iOS移动应用程序,通过本地windows和linux应用程序或你的网络浏览器加入discord服务器。

请点击以下链接,加入IMBS对话服务器。

讨论区服务器

新闻

我们需要您的帮助!

如果你觉得每周或每月投资几个小时来帮助我们实现我们的目标,不要犹豫,请点击 "加入我们 "按钮或给我们发电子邮件。

加入我们

我们的病人指南是以PDF文件形式提供的。

它包括对IMBS的快速概述以及社区和联系信息。

下载

我们的医生指南是以PDF文件形式提供的。

它包括对IMBS诊断和社区的快速概述,以及联系信息。

作为病人,这可以让你向你的全科医生交出第一份疾病描述。

作为一名医生,这让你对该综合征及其诊断空间有了初步的了解。

下载

我们的虚拟主机和应用是基于各种Java开源项目的发展。

由于我们的项目主要是在GitHub下进行的,从现在开始可以通过GitHub的赞助计划来支持我们。

我们欢迎每个人成为我们项目的赞助人!

赞助链接

为了协调研究、电子邮件活动和一般讨论,现在有一个可供使用的迪科德服务器。

请点击 邀请链接 加入。

反馈信息

患者信息

定义

肠道代谢性狐臭综合征(IMBS)定义了一种狐臭,它是由有气味的肠道代谢物引起的,这些代谢物通过肠道和肝脏的代谢,通过皮肤排出体外。

IMBS代表了一组由不同基础疾病引起的微妙不同的综合征,它们的共同特点是病人患有慢性体味。这严重影响了他们的生活质量,不仅限于此,尤其是在工作环境中。

经典的医学/皮肤学观点

目前经典医疗机构的支持是极其有限的。在过去的几十年里,溴化病领域的官方研究是可以忽略的,一般的肠道研究还没有将他们的研究与皮肤病领域联系起来。

关于狐臭的经典皮肤学研究 [1] 大多集中在只有少量改善效果的局部治疗或通过手术切除腋窝皮肤腺体。 在三甲胺尿症(TMAU)的情况下,患者目前大多只接受饮食建议,或在某些情况下被开具不可吸收的抗生素。 [2] .

最近的肠道医学研究

较新的研究假说更注重于将肠道作为溴湿病和口臭症状的来源 [3] .已经很清楚,三甲胺,也就是造成TMAU 1型的气味化合物,只是肠道代谢中各种气味代谢物中的一个小角色。 还有一些众所周知的参与者,如羧酸盐(如丁酸盐、异戊酸盐)、胺、硫化合物、氨、甲硫醇和吲哚等等。当不同的代谢物通过它们的代谢循环时,它们以不同的数量通过肠壁,穿过肠道上皮层,从而最终进入血流,进入肝脏。 在肝脏代谢不能处理肠道代谢物的情况下,代谢物会通过肺部气体交换和皮肤外层汗腺排出体外。

Bromhidrosis疾病和代谢物及基因概述

反馈信息

治疗方法
症状 治疗 效果 经医学研究批准
鱼的体味 饮食/减少含有TMA的鱼和含有胆碱、甜菜碱和肉碱的食物 75%
鱼腥味(TMAU 2型 短时间内开具不可逆的抗生素处方 75%
鱼的体味 补充核黄素 50%
鱼和粪便的体味(TMAU 2型 补充叶酸或MTHF 未知 没有
鱼和粪便的体味(TMAU 2型 补充维生素B12 未知 没有
鱼和粪便的体味(TMAU 2型 补充维生素B6 未知 没有
鱼和粪便的体味(TMAU 2型 补充SAMe 未知 没有
鱼和粪便的体味(TMAU 2型 饮食中避免使用半胱氨酸 未知 没有
粪便的体味 补充甘氨酸、丝氨酸 未知 没有
粪便的体味 补充胆碱和叶酸 未知 没有
粪便的体味 避免使用苯甲酸盐、肉桂酸盐和水杨酸盐 未知 没有
粪便的体味 避免使用苯并咪唑类药物,如质子泵抑制剂。 未知 没有
粪便的体味 避免压力 未知 没有
粪便的体味 Champex/Deodorex 10% 没有
粪便的体味 饮食中避免使用D-核糖 未知 没有
粪便的体味 饮食上避免使用磷酸+葡萄糖/果糖(如可口可乐)。 未知 没有
腐烂的鸡蛋体味 没有
类似尿液的体味 减少蛋白质的饮食+短期内开具不可逆的抗生素处方 未知 没有
类似尿液的体味 补充苯甲酸钠(必须咨询专业医生)。 未知 没有
腋窝体味 强力抗汗剂 10%
汗水般的体味 全身使用止汗剂+除臭剂组合 10% 没有
汗水/呕吐物/汗脚如体味 补充牛磺酸、镁和钾 50% 没有
汗水/呕吐物/汗脚如体味 每天进行肠道清洁,例如使用Macrogol(可能有危险 - 必须事先咨询专业医生)。 30% 没有
汗水/呕吐物/汗脚如体味 酪氨酸补充剂 10% 没有
呕吐物/脚汗,并伴有类似尿液的体味 补充苯甲酸钠(必须咨询专业医生)。 未知 没有
呕吐物般的体味 锰的补充剂 10% 没有
卷心菜般的体味/口臭 饮食 未知 没有
IBS-C(便秘 Topinambur粉(长链碳水化合物降解为果糖)[警告:体味升高] 。 15% 没有
IBS-C(便秘 氧化镁+柠檬酸盐 15% 没有

反馈信息

研究新闻

代谢标志物。

  • 甘氨酸

  • 瓜氨酸

  • 胆碱

  • 甜菜碱

  • 三甲胺(TMA

基因。

  • BHMT

  • BHMT2

  • DMGDH

  • FMO3

  • CPS1

链接

一篇研究论文更深入地调查了发生在2型三甲胺尿症患者身上的微生物成分的改变。

他们的调查首次揭示了从改变的微生物代谢物到人类代谢中的神经系统途径的可能干扰联系。

一些假设的代谢物的改变是。

  • SCFAs(乳酸盐、乙酸盐、丁酸盐、丙酸盐...)。

  • ...

假设对人体代谢物和酶的干扰。

  • 谷氨酸

  • GABA

  • 羟色胺

  • 色氨酸

  • 喹诺酮

  • 去甲肾上腺素

  • 多巴胺

  • 磷脂酰乙醇胺N-甲基转移酶(PEMT

  • 磷脂酰乙醇胺

  • 磷脂酰胆碱

  • 胆碱

  • 甜菜碱运输

链接

2019年5月的一项研究发现,在肠易激综合征(IBS)患者的尿液样本中,各种化合物都有所升高。

  • 二甲基甘氨酸

  • 谷氨酰胺

  • 赖氨酸和赖氨酸化合物

  • 色氨酸化合物

  • 鸟氨酸

  • 咪唑丙酸酯

  • 二甲基鸟苷

  • 丝氨酸

特别是升高的二甲基甘氨酸化合物也被称为二甲基甘氨酸尿症,这也会引起鱼腥味症状。

这是鱼腥味综合征(TMAU2)和IBS之间潜在的第一个联系。

链接

Jun Nishihira周围的一项小型研究试图调查香槟酒提取物(Champex)对体味和口臭的影响。

该研究的设计是基于病人的问卷调查,这使得Champex能够改善老年患者的定期体味的迹象很弱。

目前还不清楚这些结果是否会适用于IMBS患者。

链接

2020年3月,一篇新的研究论文发表了,关于使用工程聚合物体治疗三甲胺尿症的新治疗方案...

链接

反馈信息

诊断性

官方诊断测试。

  • 三甲胺尿症的尿液和基因检测 [1]

  • 二甲基甘氨酸尿症的尿液和基因检测 [2]

  • SELENBP1(口臭)的基因检测 [3]

  • 血液中的二甲亚砜症(口臭)检测 [4]

  • 在弱尿素循环障碍的情况下对高氨血症进行血液检测 [5]

反馈信息

有两份指导性文件可供下载。

第一个指南是针对病人。 患者指南

第二份指南是针对医疗从业人员的。 医生指南

这些指南可以免费复制和增殖。

如果你作为病人想第一次带着IMBS症状的话题去看例如你的全科医生,请把医生指南打印在纸上并提供给你的全科医生,以支持他/她收集相关信息。

未验证和探索性测试。

血液检查

  • 氨血检(可由你的普通医生提供

氨基酸血斑试验

尿液样本测试

从调查研究中得知的测试

  • SCFAs(包括丁酸盐和异戊酸盐)的血液与粪便的比例( [1] )

其他非特异性测试

  • PTH(甲状旁腺激素)血液检查

  • 低血钾水平

注意事项。

  • 有机酸尿症的尿液测试经常没有任何结果(在这些疾病中,所有的器官和细胞都受到影响,肾脏和肝脏不能掩盖任何代谢物)。

  • 在IMBS患者中,酶的缺乏似乎只限于肠道和肝脏的代谢,这导致肝脏和肾脏掩盖了代谢物。同样值得一提的是,丁酸盐在血液中的半衰期短于10分钟,而且( [2] ),因为该文件显示,与门静脉血液相比,丁酸盐水平在肝脏后的循环中减少了4倍。

  • 在IMBS病例中,一般来说,与尿液测试相比,血液测试能够更直接地显示出代谢物。

反馈信息

罕见病中心

我们鼓励所有病人与他们各自国家的罕见病中心联系。请做好准备,因为大多数医生对厌氧代谢物以及它们在人体代谢中的出现没有特别的认识,甚至完全没有认识。 通常情况下,了解这些代谢物的专家可以在经典的有机酸奶领域找到,但他们通常缺乏肠道疾病的专业知识。然而,他们可能是第一个接触点,可以将病人引向肠道研究诊断的专家。 为了帮助他们找到正确的联系人,你也可以把他们介绍到IMBS的主页上,在那里他们可以得到关于该疾病的详细概述。 还要让他们知道,通过尿样检查进行经典的有机酸筛查已经知道不适用于IMBS患者。

官方基因检测(德国

在德国,根据法律规定,如果要进行基因检测,患者在检测前必须接受基因咨询。 遗传咨询通常也由罕见病中心处理,因此这些中心是第一个接触点。

也有一些实验室允许私人付费,并且还提供遗传咨询。

请注意。 德国医疗保险机构现在支付少数目标基因(<=20)的必要基因测试。 这也为没有足够的私人资金进行WES或WGS筛查的IMBS患者开辟了一条新途径,要求对他们的病情进行基因测试。

反馈信息

吉诺瓦诊断公司

Genova诊断公司是一家私人服务提供商,主要提供代谢组学测试,但也提供基因组学测试。 目前,他们在美国和英国提供服务。 在通常情况下,他们与专业的全科医生一起工作,作为私人终端用户的联系人。

主页

医学诊断学

Medivere诊断公司在其网上商店向终端用户提供小型标准的血液、尿液和粪便测试。他们的服务在德国也有。

主页

瑟斯林

Cerascreen提供了一个网上商店,不仅提供例如标准的氨基酸血点测试,还提供各种标准测试。 他们的网上商店在德国有售。

主页

IFU Wolfhagen

IFU Wolfhagen在他们的网上商店提供尿液分析板等。他们的服务以德国语提供。

主页

反馈信息

氨基酸

IMBS患者所患的不同气味类型与不同的气味化合物有关。 那些有气味的化合物很多时候也是氨基酸紧密降解或合成的一部分。

下面你会发现有气味的化合物和氨基酸之间的关系。

鱼腥味/三甲胺

  • 胆碱

  • 甜菜碱

  • 卵磷脂

  • 肉碱

粪便体味/吲哚、斯卡托尔

  • 色氨酸

  • 甘氨酸

  • 丝氨酸

  • 苯丙氨酸

  • 酪氨酸

  • 组氨酸

臭蛋体味/硫磺化合物

  • 半胱氨酸

  • 蛋氨酸

  • 牛磺酸

尿液的体味/氨气

  • 鸟氨酸

  • 天冬氨酸

  • 瓜氨酸

  • 精氨酸

  • 甘氨酸

  • 丝氨酸

  • 谷氨酰胺

  • 谷氨酸

呕吐物体味/丁酸盐

  • 赖氨酸

  • 瓦林

(同时尿液体味中的氨基酸也可以适用)

汗脚/异戊酸盐

  • 亮氨酸

  • 异亮氨酸

(同时尿液体味中的氨基酸也可以适用)

腐烂的肉一样/Putrescine, Cadaverine

  • 鸟氨酸(Putrescine

  • 赖氨酸 (Cadaverine)

垃圾一样/硫化氢、二甲硫醚、甲硫醇、普鲁士碱、尸体碱、三甲胺、氨、乙醛、乙酸盐

这是前几组的混合物。 [1]

饮食方法

我们强烈建议不要在较长时期内使用任何形式的完全消除饮食。

渴望通常是身体对某些营养物质需求的一个信号。在减少饮食的情况下,不要忽视它们在某种氨基酸的背景下。

还要注意的是,列出的氨基酸只是在生化途径的边界内按同位进行分组。 有些疾病可能只影响一组中的一个氨基酸,或者只影响一组组合中的一些。

作为一个现实生活中的例子,血点氨基酸筛查显示以下氨基酸超出了正常范围。

  • 色氨酸: ++

  • 甘氨酸。++

  • 丝氨酸。++

  • 赖氨酸:-

  • 鸟氨酸。++

  • 天门冬氨酸。++

  • 组氨酸。+

符号。

  • '++'=高于正常范围的高值

  • '+'=非常高但在正常范围内

  • '-' = 非常低,但在正常范围内

  • '--'=低于正常范围

正如你所看到的,这样的氨基酸筛查可能会给出一些提示,说明在饮食中应该补充什么,减少什么。

仍然要注意的是,目前还不清楚如何对某些氨基酸水平高于或低于正常范围作出正确反应。

有一些迹象表明,某些类型的气味代谢物确实在一定程度上稳定了受伤害的肠道代谢,其他的则没有。

因此,错误的饮食消除选择也可能随着时间的推移增加对肠道细胞的损害,即使体味或口臭在一段时间内减少。

反馈信息

根据我们在病人研究中的个人观察,多汗症(广泛出汗)可以是溴化病的相关症状,但它不一定要存在。 我们认为只有一小部分病人实际上同时具有溴化吸入症和多汗症的症状。

反馈信息

肠易激综合征(IBS) [1] 被定义为胃肠道的一种慢性功能紊乱。它的特点是腹痛和/或肠道运动的改变。

我们的观察表明,大约20-30%的IMBS患者同时患有IBS,或在长期出现体味症状若干年后开始患有IBS。

另外,我们的观察显示,粪便体味似乎更可能与IBS-D有关,而汗水/呕吐物/脚汗的体味更可能与IBS-C有关。

反馈信息

下一代测序 (NGS)

简介

下一代测序(NGS)是一种允许对人类基因组的部分或整个DNA/RNA链结构进行测序的方法。 在过去十年中,NGS方法越来越多地被用作研究中的方法,以隔离与疾病及其症状的因果关系。

另请参见关于NGS和基础技术的维基百科。

NGS服务的标准

根据国家法律,不仅有官方医疗机构可向患者提供NGS服务,而且还有私人服务提供者。

如果应该利用NGS服务来获得有关潜在潜在疾病的更多信息,那么了解不同提供的服务的一些重要属性是很重要的。

  • 测序类型:全基因组(WGS) [1] 或全外显子组(WES [2]

  • 覆盖范围 [3] 表示测序覆盖同一目标参考区的次数。

  • 测序结果以文件格式提供。VCF(有/无注释),FASTQ,BAM

成本角度。

  • WGS 20x : ~ 600€

  • WES 20x : ~ 400€

(价格确实随着时间的推移和不同的服务提供商之间的变化而大量变化)

对医疗代表评估的要求。

  • 目前,我们接受至少20倍于目标区域的覆盖率,以便进行医学相关的解释。

  • WGS包括内含子区域,但还不容易解释,因为内含子区域容易出现高变异,但随着时间的推移,这种情况会稳步改善(所以今天的数据在未来可能会被利用,只是通过较新的软件应用和变异数据库中的新条目对数据进行重新解释。

关于23andMe等祖先服务。

的祖先服务,如 23andMe 在外显子组区域的哪些部分是目标/覆盖的以及目标区域被读取的频率(读取覆盖率)方面非常有限。23andme的过程依赖于基因分型方法,而不是WES或WGS。 [4]

我们不推荐医学相关调查的祖先服务,相反,我们建议至少由服务提供商提供WES 20倍的报价,该服务提供商至少提供有注释的VCF文件,甚至更好的是另外提供包含原始测序信息的FASTQ文件。

反馈信息

医学上已知的基因

一组有限的基因缺陷已经知道与慢性体味和/或口臭有关。

  • FMO3 (三甲胺尿症) [1]

  • DMGDH (二甲基甘氨酸脱氢酶缺乏症) [2]

  • SELENBP1(甲硫醇氧化酶缺乏症/EHMTO)。 [3]

探索性的候选基因

对于其他体味或口臭类型,到目前为止还没有正式的基因缺陷。 但有一些可能涉及的候选基因,因为它们编码与某些气味代谢物有关的生化途径周围的酶、转运器、受体。

汗水或呕吐物,脚汗如体味/羧酸盐,丁酸盐,异戊酸盐...

直接酶的缺陷。

  • ACSM2B

  • ACSM5

  • ACSM2A

间接参与的缺陷。

  • CPS1(也作为良性合格变体,已知甘氨酸水平升高)。

还有可能间接参与的基因。

  • ǞǞǞ

  • ATP10B

  • AGXT2

  • SLC28A1

  • SLC23A1

  • SLC17A4

  • SLC10A2

粪便体味 / 吲哚,斯卡托尔

  • BHMT2

  • 医学博士

  • CYP2B

  • CYP2A6

粪便和汗水般的体味/IBS-C和IBS-D相关基因

  • GUCY2C

  • TRPV3

  • SCN5A

  • AQP8

  • IDO1

  • PGP

  • GAD2

  • FAAH

  • NPSR1

  • FUT2

半自动化的基因报告

我们根据IMBS患者队列的基因分析结果提供半自动化报告。

  • 至少有两名患者匹配的肠道和肝脏表达的基因。 报告

  • IMBS患者队列的基因与IBS研究出版物的基因相匹配。 报告

补充说明

在慢性体臭病例中,不一定总是存在遗传缺陷。也有病人报告说症状是在食物中毒或抗生素治疗后开始的。

所以要注意,在这些情况下进行代谢组分析会发现更多的信息。

反馈信息

在代谢组研究中,已经观察到IMBS患者的以下代谢标志物可能超出正常范围。

  • 苯甲酸盐 / 苯甲酸

  • 马尿酸/马尿酸

  • 酒石酸盐/酒石酸

  • 乌洛托品/乌洛托酸

  • 顺式乌头碱/顺式乌头酸

  • 琥珀酸/琥珀酸

  • 异柠檬酸盐

  • 富马酸盐

  • 羟甲基戊二酸

  • 组氨酸

  • 牛磺酸

  • 苏氨酸(Threonine

  • 色氨酸

  • 甘氨酸

  • 丝氨酸

  • 磷脂酰亚胺

  • 梵尼曼德拉特

  • 高香草酸盐

  • 鸟氨酸

  • 瓜氨酸

  • 焦谷氨酸(Pyroglutamate

  • 对羟基苯乙酸酯

  • 安塞林

  • 肉毒杆菌素

  • 1-甲基组氨酸

  • β-丙氨酸

  • 亚油酸/亚油酸

  • 甲状旁腺激素(PTH

反馈信息

对于显示出类似粪便体味的IMBS患者亚组,代谢物吲哚和次级斯卡托是重点,因为这些代谢物正在创造一种强烈的类似粪便的气味。

我们预计在这些亚组中至少有三种不同类型的致病原因。

  • 直接降解吲哚的酶缺乏,如CYP2E1、CYP2B、......。

  • 胆碱->甘氨酸降解途径中的酶缺陷(BHMT2,甲基四氢叶酸群)。

  • 下级甘氨酸+苯甲酸盐->海马酸盐降解途径中的酶缺陷

硫代烃途径形成色氨酸和吲哚的途径

生长激素途径 [1] 是一条微生物途径,负责结合吲哚和甘氨酸/丝氨酸进行色氨酸的生物合成。 [2] .

由于其前体甘氨酸和丝氨酸以及产物色氨酸都参与其中,这些氨基酸的人体降解途径可能与吲哚的升高形成有很大关系。

同样非常重要的是谷氨酰胺和谷氨酸,因为它们与吲哚合成的第二种前体蒽醌的来源有关。

胆碱->甘氨酸的降解途径

一组粪便体臭患者确实也显示出三甲胺尿症的尿液测试阳性。这表明在肠道区域形成了升高的三甲胺(TMA)水平。 其中一个原因可能是胆碱吸收和降解受损,导致胆碱在肠腔内降解为TMA的程度升高。 由于胆碱的降解途径也影响到甘氨酸和丝氨酸的可用性,它是一个有希望的候选分支,也是造成吲哚浓度升高的原因。

对于这个亚群,补充叶酸可能是有帮助的,因为叶酸支持胆碱、甜菜碱->甘氨酸、丝氨酸的降解。

甘氨酸+苯甲酸盐->海马酸盐降解途径

在粪便体味患者的代谢组分析结果中,我们观察到苯甲酸盐升高,同时海马酸盐水平低于正常范围。 甘氨酸水平通常较低,但在正常范围内。

这与甘氨酸的解毒机制有关 [3] 在这一亚组的IMBS患者中,由于甘氨酸或丝氨酸的可用性太低,这可能会受到影响。

如果甘氨酸和丝氨酸可用性过低的迹象是正确的,那么低水平将损害胆汁酸盐与甘氨酸的结合,并降低肠腔内甘氨酸的可用性。

甘氨酸/牛磺酸的配比将发生变化,吲哚+甘氨酸的色氨酸形成可能受到影响,结果是肠腔内吲哚浓度升高。

高谷氨酸、甘氨酸、鸟氨酸、瓜氨酸、色氨酸、苯丙氨酸、酪氨酸、蛋氨酸、牛磺酸、BCAAs、氨和低精氨酸、谷氨酰胺、赖氨酸 -> 尿素循环缺乏症

与氨降解有关的各种氨基酸的升高已被发现与过渡性高氨血症有关。这表明尿素循环途径中的第二个基因缺陷可能是粪便气味的来源。

CYP酶家族

一些CYP家族的酶已知可以将吲哚降解为气味较小的代谢物。

例如:。

  • CYP2E1, CYP2B [4]

这些都是可能导致吲哚降解障碍的酶缺陷的突出候选者。

反馈信息

对于IMBS患者亚组,表现为类似呕吐物、汗水或汗脚的体味,主要的气味驱动代谢物来自羧酸盐组。

  • 丁酸盐(类似呕吐物

  • 异戊酸盐(像汗脚一样,很俗)。

  • 己酸酯

我们预计至少有两种不同类型的致病原因。

  • 直接降解丁酸盐或异戊酸盐的酶的缺陷,如如 ACSM2B , ...

  • 肠道屏障细胞的线粒体损伤,例如通过这些细胞的局部高氨值(非系统性)。

ACSM2B和降解途径的缺陷(IMBS Carboxylate Type 1)。

与其他有气味的代谢物相比,羧酸盐基团是肠道屏障细胞和肝脏的主要能量来源。

众所周知的术语 "短链脂肪酸"(SCFAs)主要是指羧酸盐的一个子集,但也包括例如它们的甲基化形式。

以下基因和酶是酶缺乏症的突出候选者。

  • ACSM2B / EC 6.2.1.2 丁酸CoA连接酶

  • 编码异戊酸酯CoA连接酶的一个可能的未知基因

重要的是,例如ACSM2B也参与水杨酸盐、苯甲酸盐和苯乙酸盐,但范围较小。

也很重要。

  • 芒格

是这些酶的辅助因子。 补充这些可以提高酶的效率。

氨气对肠道屏障细胞的线粒体损害(IMBS 羧酸型 2 / IMBS CPS1)。

如果肠道屏障细胞的线粒体活动受到损害,则可能出现另一种致病情况。 其中一个原因可能是细胞内氨的浓度升高,这将影响从结肠吸收的短链酸(羧酸盐)的降解。 在这种情况下,后期进展的一个典型标志是IBS-C(便秘)症状,这是由神经功能损伤引起的,例如在结肠的西格玛。这些症状可以立即出现,也可以在第一次出现狐臭症状多年后出现。

食物清单(不好)。

  • 奶酪(高谷氨酸盐

  • 红肉(氨基酸含量高

代谢组生物标志物

在这种情况下,可能的观察是。

  • 血液中鸟氨酸、甘氨酸、丝氨酸水平略有升高

  • 血液中的色氨酸、组氨酸、苏氨酸水平也可能略有升高

  • 主要是尿液中瓜氨酸水平升高

  • 低血钾(氨通过与钾受体结合间接损害钾的摄取

  • 尿液中的苯甲酸酯类/安息香酸含量低

在苯甲酸钠处理期间。

  • 尿液中的海嘌呤/海嘌呤酸水平非常高

遗传标记

  • 编码碳酰磷酸合成酶1的CPS1基因的弱缺陷(尿素循环障碍)。

  • 示例变体:rs1047883 [1]

CPS1的缺陷也包括那些被标记为外周血中高氨血症的良性缺陷。特别是那些也与血液中甘氨酸水平升高有关的。

鉴定为良性与IMBS中的良性无关,因为在IMBS病例中,肠道屏障细胞中的局部高氨值目前不一定能通过血液检查进行量化。

治疗

  • 口服苯甲酸钠的标准高氨治疗(<5克,一天内分配)在这里可以显示出非常好的效果,减少IBS-C症状的神经疼痛感。

  • 减少甘氨酸和丝氨酸(或一般的蛋白质)的饮食量

  • 减少谷氨酰胺、谷氨酸、天门冬氨酸、赖氨酸和鸟氨酸的饮食量

  • 减少对钙的摄取

  • 增加镁(氧化物或碳酸盐,不仅仅是柠檬酸盐!)的吸收量

  • 增加钾的吸收

  • 补充Topinambur作为菊粉补充剂,菊粉作为长链碳水化合物主要在大肠道内降解为果糖(增加气味,但改善了米氏菌的氨损害--应在苯甲酸钠治疗1周后首次服用)。

补充意见

  • 还有一个观察结果是,结肠蠕动受损导致脂肪在结肠中堆积,这可能是与SCFAs浓度增加有关的另一个方面。

  • 碳酸镁和氧化镁(也包括所有其他碳酸盐)应少量服用(每天1粒),并且要注意,因为它们很容易使肠道pH值升高到10,从而伤害肠壁。

反馈信息

癌症研究

IMBS的亚型与丁酸盐之间的联系

癌症研究领域乍一看似乎与IMBS研究相去甚远。

有趣的是,如果我们看一下IMBS的一些病人亚群的生化情况和他们受影响的代谢化合物,就会发现情况完全相反。

有的病人报告说有一种非常强烈的 "呕吐物 "般的体味。已知具有这种气味特征的相关代谢物是水溶液中的丁酸盐。

什么是丁酸盐?

丁酸盐是丁酸的盐形式,众所周知,丁酸是造成呕吐物气味的主要因素。

作为盐,它可以有各种不同的阳离子组合,如。

  • 钠(Na+)

  • 镁 (Mg2+)

  • 钾 (K+)

  • 钙(Ca2+)

例如,丁酸钠也通常以补充剂的形式在柜台出售。

丁酸盐在体外抑制癌症生长,但在血流中不够稳定

在癌症研究领域,已经观察到丁酸盐在体外对癌细胞有强烈的生长抑制作用。 [1]

不幸的是,试图利用丁酸盐溶液作为血液输注的探索性研究,未能使丁酸盐在血液循环中稳定下来。 事实证明,在被人体细胞消耗和降解之前,丁酸盐的稳定半时间非常短,不到10分钟。 [2]

丁酸盐在IBD中的相关性

炎症性肠病(IBS)方面的最新研究显示,现在有一些诊断方面的进展,例如,在IBD患者的一个小样本组中发现了 "自然 "升高的异丁酸盐水平。 [3]

换句话说,像丁酸盐或异丁酸盐这样的羧酸盐可以在肠道->肝脏轴中升高,显然不会造成任何伤害,因为IBD患者除了肠道炎症问题外,通常被认为是健康的。

由此产生的假说

这个新的方向产生了两个假设。

  • 一般来说,丁酸盐或羧酸盐(如异戊酸盐)在IMBS患者群体中也可能升高,因为它们的气味与这些化合物的特征完全一致。

  • 对于癌症治疗的支持,可能通过口服过量的补充剂(可能导致溴化血症症状)很容易再现类似的血液丁酸盐水平,这可能导致抑制癌症的生长,如果癌症位于肠道->肝脏血液轴。

额外的个人观察

  • 作为对位于降结肠的结直肠肿瘤样本的调查和可视化的一部分,我们对肿瘤样本和靠近肿瘤位置的健康肠壁样本进行了双重mRNA表达分析。

  • 酶的表达水平的比较表明,不仅乳酸脱氢酶(LDH)被过度表达,而且例如丁酰-CoA合成酶(EC 6.2.1.2)也被过度表达。这可能给出了第一个提示,即厌氧的癌症内部代谢也通过反向反应支持其ATP供应,该反应导致丁酸合成,就像典型的细菌代谢。

  • 一个理论上的结果是假设丁酸盐水平的增加会抑制内部癌症核心细胞的ATP供应,因此会减少癌症的生长。这一假设性的结果已经被之前的实验调查所验证。(见上述文本中的参考文献)

反馈信息

虚拟主机费用

www.gofundme.com

你可以帮助赞助每年整体虚拟主机费用的一部分,包括证书、域名、服务器和语言翻译。

通过www.gofundme.com 进行捐赠

www.github.com

你也可以通过每月定期赞助的方式支持我们的网络托管或API集成项目,将其纳入全球各种医学研究数据库。

赞助商通过www.github.com

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Indoles Derived From Glucobrassicin: Cancer Chemoprevention by Indole-3-Carbinol and 3,3'-Diindolylmethane Williams DE 2021-10-01 PMC
Trimethylamine-N-Oxide Pathway: A Potential Target for the Treatment of MAFLD Li X, Hong J, Wang Y 2021-10-01 PMC
Identification of Specific Substances in the FAIMS Spectra of Complex Mixtures Using Deep Learning Li H, Pan J, Zeng H 2021-09-14 PMC
A simplified LC-MS/MS method for the quantification of the cardiovascular disease biomarker trimethylamine-N-oxide and i... Rox K, Rath S, Pieper DH 2021-03-26 PMC
The Accumulation and Molecular Effects of Trimethylamine N-Oxide on Metabolic Tissues: It’s Not All Bad Krueger ES, Lloyd TS, Tessem JS 2021-08-21 PMC
Elucidation of an anaerobic pathway for metabolism of l-carnitine–derived γ-butyrobetaine to trimethylamine in human gut... Rajakovich LJ, Fu B, Bollenbach M 2021-08-06 PMC
Multi-Pharmacology of Berberine in Atherosclerosis and Metabolic Diseases: Potential Contribution of Gut Microbiota Yang S, Li D, Yu Z 2021-07-09 PMC
Differential Diagnosis of Chorea—HIV Infection Delays Diagnosis of Huntington’s Disease by Years Achenbach J, Faissner S, Saft C 2021-05-27 PMC
Trimethylaminuria and Vascular Complications Oliveira-Filho AF, Medeiros PF, Velloso ... 2021-05-03 PMC
A Case of Fishy Smell-Fish Malodor Syndrome Wang AW, Greenberg PD, Saul SR 2021-05-03 PMC
Trimethylamine modulates dauer formation, neurodegeneration, and lifespan through tyra‐3/daf‐11 signaling in Caenorhabdi... Khanna A, Sellegounder D, Kumar J 2021-04-05 PMC
Trimethylamine-N-Oxide Levels Are Similar in Asymptomatic vs. Symptomatic Cerebrovascular Atherosclerosis Heyse M, Schneider C, Monostori P 2021-03-19 PMC
Cancer interception by interceptor molecules: mechanistic, preclinical and human translational studies with chlorophylls Dashwood RH 2021-03-06 PMC
Flavin-Containing Monooxygenases Are Conserved Regulators of Stress Resistance and Metabolism Huang S, Howington MB, Dobry CJ 2021-02-12 PMC
Trimethylamine N-oxide (TMAO) in human health Gatarek P, Kaluzna-Czaplinska J 2021-02-11 PMC
Genomic Insights into Adaptations of Trimethylamine-Utilizing Methanogens to Diverse Habitats, Including the Human Gut de la Cuesta-Zuluaga J, Spector TD, Youn... 2021-02-09 PMC
Gut-Brain Axis Cross-Talk and Limbic Disorders as Biological Basis of Secondary TMAU Donato L, Alibrandi S, Scimone C 2021-01-31 PMC
Solvent Accessibility of Residues Undergoing Pathogenic Variations in Humans: From Protein Structures to Protein Sequenc... Savojardo C, Manfredi M, Martelli PL 2021-01-07 PMC
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Le Carbone prevents liver damage in non-alcoholic steatohepatitis-hepatocellular carcinoma mouse model via AMPKα-SIRT1 s... Afrin MR, Arumugam S, Pitchaimani V 2021-01-05 PMC
Role of Gut Microbiota and Their Metabolites on Atherosclerosis, Hypertension and Human Blood Platelet Function: A Revie... Duttaroy AK 2021-01-03 PMC
Choline Acetyltransferase Induces the Functional Regeneration of the Salivary Gland in Aging SAMP1/Kl -/- Mice Toan NK, Tai NC, Kim SA 2021-01-02 PMC
Ancestral reconstruction of mammalian FMO1 enables structural determination, revealing unique features that explain its ... Bailleul G, Nicoll CR, Mascotti ML 2020-12-25 PMC
How Can Drug Metabolism and Transporter Genetics Inform Psychotropic Prescribing? Carvalho Henriques B, Yang EH, Lapetina ... 2020-12-08 PMC
Use of Flavin-Containing Monooxygenases for Conversion of Trimethylamine in Salmon Protein Hydrolysates Goris M, Puntervoll P, Rojo D 2020-11-24 PMC
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Sexuality in Persons With Hidradenitis Suppurativa: Factors Associated With Sexual Desire and Functioning Impairment Quinto RM, Mastroeni S, Sampogna F 2021-10-07 PMC
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Pain as Defining Feature of Health Status and Prominent Therapeutic Target in Patients with Hidradenitis Suppurativa Sampogna F, Campana I, Fania L 2021-08-18 PMC
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Something to Sweat About: Two Cases of Dupilumab-Induced Hyperhidrosis and Bromhidrosis Rowane M, Valencia R, Schend J 2020-05-20 PMC
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Systematic review of immunomodulatory therapies for hidradenitis suppurativa Lim SY, Oon HH 2019-05-13 PMC
Modified Suction-Assisted Cartilage Shaver for Axillary Osmidrosis Tseng YJ, Lee CH, Lin SH 2019-05-08 PMC
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The Treatment of Axillary Odor: A Network Meta-Analysis Sun P, Wang Y, Bi M 2019-04-14 PMC
Integrated Transcriptomic and Proteomic Analysis of Human Eccrine Sweat Glands Identifies Missing and Novel Proteins Na CH, Sharma N, Madugundu AK 2019-04-12 PMC
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The Effectiveness of Local Surgical Technique in Treatment of Axillary Bromhidrosis Van TN, Manh TN, Minh PP 2019-01-29 PMC
Hurley III Hidradenitis Suppurativa Has an Aggressive Disease Course Vanlaerhoven AM, Ardon CB, van Straalen ... 2018-08-27 PMC
Sphingomonas paucimobilis empyema caused by remote foreign body aspiration Yuan J, Treadwell T 2018-04-11 PMC
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Safety of Adalimumab Dosed Every Week and Every Other Week: Focus on Patients with Hidradenitis Suppurativa or Psoriasis Ryan C, Sobell JM, Leonardi CL 2018-01-27 PMC
Intralesional Diode Laser 1064 nm for the Treatment of Hidradenitis Suppurativa: A Report of Twenty Patients Fabbrocini G, França K, Lotti T 2018-01-07 PMC
Terminal Deoxynucleotidyl Transferase-Mediated Deoxyuridine Triphosphate Nick End Labeling (TUNEL) Assay to Characterize... Lee JM, Park JH, Kim BY 2017-12-26 PMC
Case series: The modified skoog approach for definitive management of severe hidradenitis suppurativa of the axilla Young Sing Q, Mohammed F, Mooteeram J 2017-10-25 PMC
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Effectiveness and Complications of Improved Liposuction–Curettage Through Mini-Incisions for the Treatment of Axillary O... Yang H, Xu G, Huang CL 2017-09-20 PMC
Dermoscopy of Yellow Concretions on Axillary Hair Cervantes J, Johr RJ, Tosti A 2017-08-22 PMC
The curative effect of liposuction curettage in the treatment of bromhidrosis: A meta-analysis Zhang L, Chen F, Kong J 2017-08-18 PMC
A novel organotypic 3D sweat gland model with physiological functionality Klaka P, Grüdl S, Banowski B 2017-08-10 PMC
Hidradenitis suppurativa: an update on connecting the tracts Smith MK, Nicholson CL, Parks-Miller A 2017-07-28 PMC
Descriptive Epidemiology of Hidradenitis Suppurativa in Greece: A Study of 152 Cases Katoulis AC, Liakou AI, Rotsiamis N 2017-05-17 PMC
A missense variant of the ABCC11 gene is associated with Axillary Osmidrosis susceptibility and clinical phenotypes in t... Ren Y, Liu W, Chen J 2017-05-09 PMC
Hidradenitis suppurativa: from pathogenesis to diagnosis and treatment Napolitano M, Megna M, Timoshchuk EA 2017-04-19 PMC
Medical and Surgical Treatment of Hidradenitis Suppurativa: A Review Scuderi N, Monfrecola A, Dessy LA 2017-03-21 PMC
Oxybutynin as an alternative treatment for hyperhidrosis Delort S, Marchi E, Corrêa MA PMC
Clinical and Molecular Evidence of ABCC11 Protein Expression in Axillary Apocrine Glands of Patients with Axillary Osmid... Toyoda Y, Takada T, Gomi T 2017-02-15 PMC
Working Up a Good Sweat – The Challenges of Standardising Sweat Collection for Metabolomics Analysis Hussain JN, Mantri N, Cohen MM PMC
Botulinum Toxin Off-Label Use in Dermatology: A Review Campanati A, Martina E, Giuliodori K 2017-02-01 PMC
Comparative Study of Efficacy and Safety of Botulinum Toxin a Injections and Subcutaneous Curettage in the Treatment of ... Budamakuntla L, Loganathan E, George A PMC
MMP8 Is Increased in Lesions and Blood of Acne Inversa Patients: A Potential Link to Skin Destruction and Metabolic Alte... Tsaousi A, Witte E, Witte K 2016-10-23 PMC
The Effect of Smoking and Age on the Response to First-Line Therapy of Hidradenitis Suppurativa: An Institutional Retros... Denny G, Anadkat M 2016-09-28 PMC
Clinical and epidemiological features of coryneform skin infections at a tertiary hospital Pinto M, Hundi GK, Bhat RM PMC
Diagnosis of Human Axillary Osmidrosis by Genotyping of the Human ABCC11 Gene: Clinical Practice and Basic Scientific Ev... Toyoda Y, Gomi T, Nakagawa H 2016-02-23 PMC
Pitted keratolysis de Almeida Jr HL, Siqueira RN, Meireles ... PMC
Treatment of Diffuse Planar Xanthoma of the Face after One Session of 1,444-nm Neodymium-Doped Yttrium Aluminium Garnet ... Lee JM, Chun SH, So BJ 2015-12-07 PMC
Perianal Crohn’s disease and hidradenitis suppurativa: a possible common immunological scenario Giudici F, Maggi L, Santi R 2015-07-22 PMC
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Quality of life in patients with primary axillary hyperhidrosis before and after treatment with fractionated microneedle... Abtahi-Naeini B, Naeini FF, Adibi N PMC
Actualities of Management of Aural, Nasal, and Throat Foreign Bodies Oreh A, Folorunsho D, Ibekwe T PMC
Rapid Stress System Drives Chemical Transfer of Fear from Sender to Receiver de Groot JH, Smeets MA, Semin GR 2015-02-27 PMC
Minimally Invasive Surgery for Axillary Osmidrosis Using a Combination of Subcutaneous Tissue Removal and a 1,444-nm Nd:... Lee SG, Ryu HJ, Kim IH 2014-11-26 PMC
Surgical treatment of axillary hyperhidrosis by suction-curettage of sweat glands de Rezende RM, Luz FB PMC
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Zinc Therapy in Dermatology: A Review Gupta M, Mahajan VK, Mehta KS 2014-07-10 PMC
Therapeutic effect of Botulinum toxin-A in 88 patients with Trigeminal Neuralgia with 14-month follow-up Li S, Lian YJ, Chen Y 2014-06-22 PMC
A Prospective, Long-Term Follow-Up Study of 1,444 nm Nd:YAG Laser: A New Modality for Treating Axillary Bromhidrosis Jung SK, Jang HW, Kim HJ 2014-04-30 PMC
Evaluation of anxiety and depression prevalence in patients with primary severe hyperhidrosis Bragança GM, Lima SO, Pinto AF Neto PMC
Hidradenitis suppurativa: a common and burdensome, yet under-recognised, inflammatory skin disease Dufour DN, Emtestam L, Jemec GB 2014-02-24 PMC
Subdermal Coagulation Treatment of Axillary Bromhidrosis by 1,444 nm Nd:YAG Laser: A Comparison with Surgical Treatment Lee KG, Kim SA, Yi SM 2014-02-17 PMC
Sweat Gland Progenitors in Development, Homeostasis, and Wound Repair Lu C, Fuchs E PMC
Turning the tide: a history and review of hyperhidrosis treatment Lee KY, Levell NJ 2014-01-07 PMC
Acne inversa goes an extra mile than hidradenitis suppurativa Witmanowski H, Szychta P, Stępniewski S 2013-08-27 PMC
Characterization of Staphylococcus and Corynebacterium Clusters in the Human Axillary Region Callewaert C, Kerckhof FM, Granitsiotis ... 2013-08-12 PMC
Skin care: Historical and contemporary views AlGhamdi KM, AlHomoudi FA, Khurram H 2013-03-14 PMC
Acne inversa of the scrotum and penis – aggressive urological treatment Gibas A, Matuszewski M, Michajłowski I 2012-09-04 PMC
Treatment of Axillary Osmidrosis Using a Subcutaneous Pulsed Nd-YAG Laser Kim D, Kim J, Yeo H 2012-03-14 PMC
Advances in Electronic-Nose Technologies Developed for Biomedical Applications Wilson AD, Baietto M 2011-01-19 PMC
Multiple Intranasal Foreign Bodies: An Incidental Diagnosis Habibullah MA, Bhat SS, Hegde K S 2010-09-15 PMC
Syringomas Treated by Intralesional Insulated Needles without Epidermal Damage Hong SK, Lee HJ, Cho SH 2010-08-05 PMC
Psychological interventions in the management of common skin conditions Shenefelt PD 2010-03-26 PMC
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Vegetal Compounds as Sources of Prophylactic and Therapeutic Agents in Dentistry Milutinovici RA, Chioran D, Buzatu R 2021-10-10 PMC
Application of a protective sleeve is associated with decreased occupational anxiety during endotracheal intubation: a r... Chen C, Shen N, Chen L 2021-10-22 PMC
Acupuncture: A Promising Approach for Comorbid Depression and Insomnia in Perimenopause Zhao FY, Fu QQ, Spencer SJ 2021-10-12 PMC
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The use of ketogenic diets in cancer patients: a systematic review Römer M, Dörfler J, Huebner J 2021-04-03 PMC
Care need and dry mouth as risk indicators for impaired taste and smell Hummelsheim MZ, Hamacher S, Hagemeier A 2021-10-14 PMC
Effect of fixed orthodontic appliances on self-assessment and diagnosis of halitosis in undergraduate dental students dos Santos DD, Besegato JF, Vieira SM 2021-08-30 PMC
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Complete Genome Sequence of Weissella confusa LM1 and Comparative Genomic Analysis Yuan S, Wang Y, Zhao F 2021-09-28 PMC
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The Outcomes of Enamel Matrix Derivative on Periodontal Regeneration under Diabetic Conditions Narita LE, Mester A, Onisor F 2021-10-08 PMC
Universal Predictors of Dental Students’ Attitudes towards COVID-19 Vaccination: Machine Learning-Based Approach Riad A, Huang Y, Abdulqader H 2021-10-10 PMC
Quality and Reliability of Halitosis Videos on YouTube as a Source of Information Ramadhani A, Zettira Z, Rachmawati YL 2021-10-15 PMC
Nanostructures as Targeted Therapeutics for Combating Oral Bacterial Diseases Afrasiabi S, Chiniforush N, Barikani HR 2021-10-10 PMC
Cross-cultural adaptation and validation of Malay version of Rapid Estimate of Adult Literacy in Dentistry (MREALD-30) a... Rath A, Wong M, Pannuti CM 2021-10-12 PMC
Smokeless Tobacco Initiation, Use, and Cessation in South Asia: A Qualitative Assessment Siddiqui F, Croucher R, Ahmad F 2021-04-12 PMC
Necrotising periodontal diseases and alcohol misuse - a cause of osteonecrosis? Tkacz K, Gill J, McLernon M 2021-10-15 PMC
Effects of natural extracts in the treatment of oral ulcers: A systematic review of evidence from experimental studies i... Wen SD, Sans-Serramitjana E, Santander J... 2021-10-01 PMC
Chronic kidney disease is associated with increased risk of sudden sensorineural hearing loss and Ménière’s disease: a n... Kim JY, Lee S, Cha J 2021-10-12 PMC
Killian-Jamieson Diverticulum: Management of a Rare Esophageal Diverticula Oh J, Norris A, Artigue M 2021-09-08 PMC
Effect of Severity of Chronic Periodontitis on Oral Health-Related Quality of Life SALARI A, ALAVI FN PMC
Recurrent Dysphagia Associated with Esophageal Intramural Pseudodiverticulosis Naqvi H, Yousaf MN, Sandhu G 2021-06-21 PMC
Refinement of microbiota analysis of specimens from patients with respiratory infections using next-generation sequencin... Ikegami H, Noguchi S, Fukuda K 2021-10-01 PMC
Oral health care for the critically ill: a narrative review Winning L, Lundy FT, Blackwood B 2021-10-01 PMC
Are rare diseases overlooked by medical education? Awareness of rare diseases among physicians in Poland: an explanatory... Walkowiak D, Domaradzki J 2021-09-28 PMC
Inquiry-Driven Bioinformatics Laboratory Research Module: Metagenomic Study of Student Oral Microbes Ho Pao C, Choi SC, Lok SY 2021-06-30 PMC
Formulation development and evaluation of lidocaine hydrochloride loaded in chitosan-pectin-hyaluronic acid polyelectrol... Supachawaroj N, Damrongrungruang T, Lims... 2021-07-19 PMC
Trace Hydrogen Sulfide Sensing Inspired by Polyoxometalate-Mediated Aerobic Oxidation Bezdek MJ, Luo SX, Liu RY 2021-08-30 PMC
Prevalence and Drivers of COVID-19 Vaccine Hesitancy among Czech University Students: National Cross-Sectional Study Riad A, Pokorná A, Antalová N 2021-08-25 PMC
Fabrication of Humidity-Resistant Optical Fiber Sensor for Ammonia Sensing Using Diazo Resin-Photocrosslinked Films with... Ahmed S, Park Y, Okuda H 2021-09-15 PMC
Dental Problems and Prophylactic Care in Cats—Knowledge and Perceptions among Swedish Cat Owners and Communication by Ve... Oskarsson K, Axelsson Puurtinen L, Penel... 2021-08-31 PMC
Microbiome of Unilateral Chronic Rhinosinusitis: A Controlled Paired Analysis Park SC, Park IH, Lee JS 2021-09-19 PMC
Novel Approach to Dental Biofilm Management through Guided Biofilm Therapy (GBT): A Review Shrivastava D, Natoli V, Srivastava KC 2021-09-16 PMC
Natural Compounds for Preventing Ear, Nose, and Throat-Related Oral Infections Niculescu AG, Grumezescu AM 2021-09-06 PMC
Recent Trends in Exhaled Breath Diagnosis Using an Artificial Olfactory System Kim C, Raja IS, Lee JM 2021-09-14 PMC
Impact of Oral Microbiota on Flavor Perception: From Food Processing to In-Mouth Metabolization Schwartz M, Canon F, Feron G 2021-08-26 PMC
The Current and Potential Application of Medicinal Cannabis Products in Dentistry Lowe H, Toyang N, Steele B 2021-09-10 PMC
Fractal Dimension and Texture Analysis of Lesion Autofluorescence in the Evaluation of Oral Lichen Planus Treatment Effe... Jurczyszyn K, Trzeciakowski W, Kozakiewi... 2021-09-21 PMC
Adsorption of Toluene and Water over Cationic-Exchanged Y Zeolites: A DFT Exploration Hessou EP, Bédé LA, Jabraoui H 2021-09-09 PMC
Side Effects of mRNA-Based COVID-19 Vaccine: Nationwide Phase IV Study among Healthcare Workers in Slovakia Riad A, Hocková B, Kantorová L 2021-08-29 PMC
Accuracy and Reliability of Internet Resources for Information on Monoclonal Gammopathy of Undetermined Significance—Wha... Kreutzer EP, Sauer S, Kriegsmann M 2021-09-07 PMC
Oral Health as a Predictor of Physical Frailty among Rural Community-Dwelling Elderly in an Agricultural County of Taiwa... Kuo YW, Chen MY, Chang LC 2021-09-17 PMC
Neurodevelopmental Disorder Traits in Taijin-Kyofu-sho and Social Anxiety Disorder: A Cross-Sectional Study among Univer... Kajitani K, Tsuchimoto R, Omodaka Y 2021-09-17 PMC
Next-Generation Digital Biomarkers for Tuberculosis and Antibiotic Stewardship: Perspective on Novel Molecular Digital B... Brasier N, Osthoff M, De Ieso F 2021-08-19 PMC
Phylogenetic analysis and development of molecular markers for five medicinal Alpinia species based on complete plastome... Yang H, Wang L, Chen H 2021-09-22 PMC
Micro-Chamber/Thermal Extractor (µ-CTE) as a new sampling system for VOCs emitted by feces Ratiu IA, Mametov R, Ligor T 2021-09-21 PMC
A rare case of Shewanella septicemia: risk factors, environmental associations and management Latif A, Kapoor V, Vivekanandan R 2019-09-19 PMC
Assessment of the Relationship between Oral Health Behavior, Oral Hygiene, and Gingival Status of Adolescent Tobacco Con... Kumar S, Kumar A, Gupta A 2021-09-09 PMC
Self‐perceived and self‐reported breath odour and the wearing of face masks during the COVID‐19 pandemic Faria SF, Costa FO, Pereira AG 2021-07-19 PMC
Total or partial tonsillar resection (tonsillectomy or tonsillotomy) to change the quality of life for adults with recur... Laajala A, Tokola P, Autio TJ 2021-09-15 PMC
A comparison of immediate release and delayed release cysteamine in 17 patients with nephropathic cystinosis van Stein C, Klank S, Grüneberg M 2021-09-14 PMC
Antimicrobial Activity against Oral Pathogens Confirms the Use of Musa paradisiaca Fruit Stalk in Ethnodentistry Owusu-Boadi E, Akuoko Essuman M, Mensah ... 2021-09-04 PMC
A randomised clinical study investigating efficacy of a stannous fluoride toothpaste in improving gingival health after ... Acherkouk A, Patel N, Butler A 2021-09-12 PMC
mRNA-based vs viral vector-based COVID-19 vaccines 2021-09-11 PMC
Evaluation of the Antimicrobial Activity of Leaf Extracts of Acokanthera schimperi against Various Disease-Causing Bacte... Kenubih A, Belay E, Lemma K 2021-09-07 PMC
Rare Diseases of the Oral Cavity, Neck, and Pharynx Reichel CA 2021-04-30 PMC
Hydroxyapatite in Oral Care Products—A Review Chen L, Al-Bayatee S, Khurshid Z 2021-08-27 PMC
COVID-19 Pandemic: Effect of Different Face Masks on Self-Perceived Dry Mouth and Halitosis Kanzow P, Dylla V, Mahler AM 2021-08-31 PMC
Design, implementation, and evaluation of a PRECEDE-PROCEED model-based intervention for oral and dental health among pr... Ghaffari M, Rakhshanderou S, Asadpour M 2021-09-03 PMC
Oral complaints in patients with acute myeloid leukemia treated with allogeneic hematopoietic stem cell transplantation Wysocka-Słowik A, Gil L, Ślebioda Z 2021-06-20 PMC
The Behavior of Patients with Obsessive-Compulsive Disorder in Dental Clinics Elkamash HM, Abuohashish HM 2021-08-30 PMC
Camellia sinensis in Dentistry: Technological Prospection and Scientific Evidence Valadas LA, de Oliveira Filho RD, Rodrig... 2021-08-30 PMC
Effects of Chlorine Dioxide on Oral Hygiene - A Systematic Review and 
Meta-analysis Kerémi B, Márta K, Farkas K PMC
Possible Immunotherapeutic Strategies Based on Carcinogen-Dependent Subgroup Classification for Oral Cancer Sun J, Tang Q, Zhang J 2021-08-23 PMC
Fusobacterium nucleatum Acts as a Pro-carcinogenic Bacterium in Colorectal Cancer: From Association to Causality Wang S, Liu Y, Li J 2021-08-20 PMC
Protein Targets of Acetaminophen Covalent Binding in Rat and Mouse Liver Studied by LC-MS/MS Geib T, Moghaddam G, Supinski A 2021-08-20 PMC
Oral, Tongue-Coating Microbiota, and Metabolic Disorders: A Novel Area of Interactive Research Li Y, Cui J, Liu Y 2021-08-20 PMC
Disruption of the oral microbiota is associated with a higher risk of relapse after allogeneic hematopoietic stem cell t... de Molla VC, Heidrich V, Bruno JS 2021-09-02 PMC
Selective and self-validating breath-level detection of hydrogen sulfide in humid air by gold nanoparticle-functionalize... Panes-Ruiz LA, Riemenschneider L, Al Cha... 2021-09-02 PMC
Prevalence and factors influencing reporting of true periodontal chief complaints: A retrospective analysis Abdulkareem AA, Imran NK, Abdulraheam RH 2020-12-22 PMC
Effect of octenidine mouthwash on plaque, gingivitis, and oral microbial growth: A systematic review Grover V, Mahendra J, Gopalakrishnan D 2021-07-06 PMC
Effects of intraoperative placement of tetracycline, tetracycline + gelatin sponge, and placebo on postoperative pain af... Patil V, Ramaraj PN, Sharma M 2021-07-15 PMC
Antibiotic adjuvant therapy for pulmonary infection in cystic fibrosis Hurley MN, Smith S, Forrester DL 2020-07-16 PMC
Zenker’s diverticulum in an 85-year-old Ugandan man Sereke SG, Bongomin F, Muyinda Z 2021-08-30 PMC
Evaluation of Herbal Mouthwashes Containing Zataria Multiflora Boiss, Frankincense and Combination Therapy on Patients w... Khoshbakht Z, Khashabi E, khodaie L 2019-07-15 PMC
Laryngopyocele in a case of bilateral mixed laryngocele: an impending airway emergency Saravanam PK, Manimaran V, Ramadhan M 2019-08-30 PMC
Metabolic Derangement in Pediatric Patient with Obesity: The Role of Ketogenic Diet as Therapeutic Tool Calcaterra V, Verduci E, Pascuzzi MC 2021-08-16 PMC
Ketogenic Diet, Physical Activity, and Hypertension—A Narrative Review Di Raimondo D, Buscemi S, Musiari G 2021-07-27 PMC
A resource of targeted mutant mouse lines for 5,061 genes Birling MC, Yoshiki A, Adams DJ PMC
A Comparison of Clinical Efficiency of Photodynamic Therapy and Topical Corticosteroid in Treatment of Oral Lichen Planu... Zborowski J, Kida D, Szarwaryn A 2021-08-19 PMC
Synthesis and Characterization of Novel Quaternary Ammonium Urethane-Dimethacrylate Monomers—A Pilot Study Chrószcz MW, Barszczewska-Rybarek IM 2021-08-17 PMC
Loop-Mediated Isothermal Amplification (LAMP): The Better Sibling of PCR? Soroka M, Wasowicz B, Rymaszewska A 2021-07-29 PMC
The Associations of Periodontopathic Bacteria and Oral Candida with Periodontal Inflamed Surface Area in Older Adults Re... Shigeishi H, Nakamura M, Oka I 2021-08-02 PMC
Selenium Status, Its Interaction with Selected Essential and Toxic Elements, and a Possible Sex-Dependent Response In Ut... Röllin HB, Channa K, Olutola B 2021-08-06 PMC
Necrotising periodontal diseases and alcohol misuse - a cause of osteonecrosis? Tkacz K, Gill J, McLernon M 2021-08-27 PMC
Topical odour management in burn patients Hayashida K, Yamakawa S 2021-08-26 PMC
Palatal mucormycosis in a patient with SARS-CoV-2 infection Venugopal A, Marya A 2021-08-16 PMC
Side Effects of mRNA-Based and Viral Vector-Based COVID-19 Vaccines among German Healthcare Workers Klugar M, Riad A, Mekhemar M 2021-08-05 PMC
标题 作者 日期 链接
Combined Metabolic Activators Decrease Liver Steatosis by Activating Mitochondrial Metabolism in Hamsters Fed with a Hig... Yang H, Mayneris-Perxachs J, Boqué N 2021-10-11 PMC
Photoreceptor cKO of OTX2 Enhances OTX2 Intercellular Transfer in the Retina and Causes Photophobia Pensieri P, Mantilleri A, Plassard D 2021-10-06 PMC
Transcriptomic profile of leg muscle during early growth and development in Haiyang yellow chicken Yin X, Wu Y, Zhang S 2021-09-20 PMC
Flaxseed Increases Animal Lifespan and Reduces Ovarian Cancer Severity by Toxically Augmenting One-Carbon Metabolism Weston WC, Hales KH, Hales DB 2021-09-18 PMC
An Integrative Co-localization (INCO) Analysis for SNV and CNV Genomic Features With an Application to Taiwan Biobank Da... Yu QY, Lu TP, Hsiao TH 2021-09-08 PMC
Rapid Evolution of Expression Levels in Hepatocellular Carcinoma Zhang F, Kuo MD 2020-03-31 PMC
Analysis of Nuclear Encoded Mitochondrial Gene Networks in Cervical Cancer Meneur C, Eswaran S, Adiga D PMC
How Perturbated Metabolites in Diabetes Mellitus Affect the Pathogenesis of Hypertension? Ning Z, Song Z, Wang C 2021-08-18 PMC
Construction of miRNA-mRNA network for the identification of key biological markers and their associated pathways in IgA... Noor F, Saleem MH, Aslam MF 2021-07-01 PMC
High-Fat Diet Alters the Retinal Transcriptome in the Absence of Gut Microbiota Dao D, Xie B, Nadeem U 2021-08-18 PMC
New loci and neuronal pathways for resilience to heat stress in cattle Cheruiyot EK, Haile-Mariam M, Cocks BG 2021-08-17 PMC
Peroxisome proliferator-activated receptor γ (PPARγ) suppresses the proliferation and metastasis of patients with urothe... Shang D, Liu Y, Zhang J 2020-12-08 PMC
Distinct Mitochondrial Pathologies Caused by Mutations of the Proximal Tubular Enzymes EHHADH and GATM Forst AL, Reichold M, Kleta R 2021-07-19 PMC
Estrogen-related receptor alpha (ERRα) is a key regulator of intestinal homeostasis and protects against colitis Tran A, Scholtes C, Songane M 2021-07-23 PMC
Genome-wide investigation identifies a rare copy-number variant burden associated with human spina bifida Wolujewicz P, Aguiar-Pulido V, AbdelAlee... 2021-03-08 PMC
High L-Carnitine Levels Impede Viral Control in Chronic Hepatitis B Virus Infection Gu S, Fu X, Ye G 2021-06-21 PMC
Rare Modifier Variants Alter the Severity of Cardiovascular Disease in Pseudoxanthoma Elasticum: Identification of Novel... De Vilder EY, Martin L, Lefthériotis G 2021-06-08 PMC
Association of Vitamin D, Zinc and Selenium Related Genetic Variants With COVID-19 Disease Severity Kotur N, Skakic A, Klaassen K 2021-06-04 PMC
Effects of Guava (Psidium guajava L.) Leaf Extract on the Metabolomics of Serum and Feces in Weaned Piglets Challenged b... Wang D, Zhou L, Zhou H 2021-05-24 PMC
Transcriptomic and metabolomic characterization of post-hatch metabolic reprogramming during hepatic development in the ... Van Every HA, Schmidt CJ 2021-05-24 PMC
Increased EHHADH Expression Predicting Poor Survival of Osteosarcoma by Integrating Weighted Gene Coexpression Network A... Cui J, Yi G, Li J 2021-05-03 PMC
Comprehensive analysis of immune-related prognostic genes in the tumour microenvironment of hepatocellular carcinoma Gao W, Li L, Han X 2021-03-31 PMC
Dissection of two routes to naïve pluripotency using different kinase inhibitors Martinez-Val A, Lynch CJ, Calvo I 2021-03-25 PMC
Construction of circRNA-Based ceRNA Network to Reveal the Role of circRNAs in the Progression and Prognosis of Hepatocel... Deng R, Cui X, Dong Y 2021-02-26 PMC
Gene expression profile of human follicle dermal papilla cells in response to Camellia japonica phytoplacenta extract Cho WK, Kim H, Paek SH 2021-02-14 PMC
Rare genetic variants affecting urine metabolite levels link population variation to inborn errors of metabolism Cheng Y, Schlosser P, Hertel J 2021-02-11 PMC
Simple sequence repeats drive genome plasticity and promote adaptive evolution in penaeid shrimp Yuan J, Zhang X, Wang M 2021-02-11 PMC
Integrating lipidomics and genomics: emerging tools to understand cardiovascular diseases Tabassum R, Ripatti S 2021-01-15 PMC
Gene networks and pathways for plasma lipid traits via multitissue multiomics systems analysis Blencowe M, Ahn IS, Saleem Z 2021-01-05 PMC
Presumed cancer‐associated retinopathy (CAR) mimicking Sudden Acquired Retinal Degeneration Syndrome (SARDS) in canines Grozdanic SD, Lazic T, Kecova H 2020-12-27 PMC
Mechanistic Modeling of Gene Regulation and Metabolism Identifies Potential Targets for Hepatocellular Carcinoma Sun R, Xu Y, Zhang H 2020-12-23 PMC
Identification of Novel MeCP2 Cancer-Associated Target Genes and Post-Translational Modifications Castro-Piedras I, Vartak D, Sharma M 2020-12-10 PMC
RNA sequencing: new technologies and applications in cancer research Hong M, Tao S, Zhang L 2020-12-04 PMC
Analysis of differentially expressed genes in oral epithelial cells infected with Fusobacterium nucleatum for revealing ... Zhang S, Li C, Zhang Z 2020-12-02 PMC
Modulation of the TGF-β signaling pathway by long noncoding RNA in hepatocellular carcinoma Han M, Liao Z, Liu F 2020-12-01 PMC
Abstracts from the 53rd European Society of Human Genetics (ESHG) Conference: Interactive e-Posters 2020-12-01 PMC
Investigation of the Impact from IL-2, IL-7, and IL-15 on the Growth and Signaling of Activated CD4+ T Cells Coppola C, Hopkins B, Huhn S 2020-10-22 PMC
Non-syndromic Cleft Palate: An Overview on Human Genetic and Environmental Risk Factors Martinelli M, Palmieri A, Carinci F 2020-10-20 PMC
Coronavirus: proteomics analysis of chicken kidney tissue infected with variant 2 (IS-1494)-like avian infectious bronch... Abdollahi H, Rezaei-Tavirani M, Ghalyanc... 2020-10-20 PMC
CRISPR screening of porcine sgRNA library identifies host factors associated with Japanese encephalitis virus replicatio... Zhao C, Liu H, Xiao T 2020-10-14 PMC
Network-Based Coexpression Analysis Identifies Functional and Prognostic Long Noncoding RNAs in Hepatocellular Carcinoma Li J, Zhou J, Kai S 2020-10-06 PMC
Selenium and at-risk pregnancy: challenges and controversies Duntas LH 2020-10-01 PMC
Functional and Clinical Characterization of Tumor-Infiltrating T Cell Subpopulations in Hepatocellular Carcinoma Li J, Zhou J, Kai S 2020-09-30 PMC
Assessment of mitochondrial function in metabolic dysfunction-associated fatty liver disease using obese mouse models Zhao QY, Ge LH, Zhang K 2020-09-18 PMC
Identification and validation of a ten-gene set variation score as a diagnostic and prognostic stratification tool in he... Zou C, Yuan C, Ye J 2020-09-15 PMC
Evolutionary history of dimethylsulfoniopropionate (DMSP) demethylation enzyme DmdA in marine bacteria Hernández L, Vicens A, Eguiarte LE 2020-09-10 PMC
Connectivity mapping of glomerular proteins identifies dimethylaminoparthenolide as a new inhibitor of diabetic kidney d... Klein J, Caubet C, Camus M 2020-09-10 PMC
Current State of Evidence: Influence of Nutritional and Nutrigenetic Factors on Immunity in the COVID-19 Pandemic Framew... Galmés S, Serra F, Palou A 2020-09-08 PMC
A Prognostic Model Based on Six Metabolism-Related Genes in Colorectal Cancer Sun YL, Zhang Y, Guo YC 2020-08-31 PMC
Role of N,N-Dimethylglycine and Its Catabolism to Sarcosine in Chromohalobacter salexigens DSM 3043 Yang T, Shao YH, Guo LZ 2020-08-18 PMC
Proteomic analysis revealed common, unique and systemic signatures in gender-dependent hepatocarcinogenesis Li H, Rong Z, Wang H 2020-08-13 PMC
Identification of potential hub genes associated with the pathogenesis and prognosis of hepatocellular carcinoma via int... Meng Z, Wu J, Liu X 2020-07-29 PMC
Metabolic pathway alterations in microvascular endothelial cells in response to hypoxia Cohen EB, Geck RC, Toker A 2020-07-09 PMC
Approaches to studying the genomic architecture of complex birth defects Taiwo TE, Cao X, Cabrera RM 2020-06-29 PMC
Activation of transcription factor circuity in 2i-induced ground state pluripotency is independent of repressive global ... Shukla R, Mjoseng HK, Thomson JP 2020-06-25 PMC
An Update on Mitochondrial Reactive Oxygen Species Production Mailloux RJ 2020-06-02 PMC
Riboflavin Deficiency—Implications for General Human Health and Inborn Errors of Metabolism Mosegaard S, Dipace G, Bross P 2020-05-28 PMC
Genomic Blueprint of Glycine Betaine Metabolism in Coral Metaorganisms and Their Contribution to Reef Nitrogen Budgets Ngugi DK, Ziegler M, Duarte CM 2020-04-30 PMC
Gene expression dynamic analysis reveals co-activation of Sonic Hedgehog and epidermal growth factor followed by dynamic... Maroufy V, Shah P, Asghari A 2020-04-14 PMC
CDK1-PLK1/SGOL2/ANLN pathway mediating abnormal cell division in cell cycle may be a critical process in hepatocellular ... Li L, Huang K, Zhao H 2020-04-10 PMC
Network-based metabolic characterization of renal cell carcinoma Pandey N, Lanke V, Vinod PK 2020-04-06 PMC
Disruption of hepatic one-carbon metabolism impairs mitochondrial function and enhances macrophage activity in methionin... Eudy BJ, McDermott CE, Fernandez G 2020-03-19 PMC
Identification of HO-1 as a novel biomarker for graft acute cellular rejection and prognosis prediction after liver tran... Jia J, Nie Y, Geng L PMC
The different expression of glycogen phosphorylases in renal clear cell renal carcinoma and chromophobe renal carcinoma Lu Y, Luo G, Zhu S 2020-02-26 PMC
One carbon metabolism and folate transporter genes: Do they factor prominently in the genetic etiology of neural tube de... Steele JW, Kim SE, Finnell RH 2020-02-13 PMC
Precision medicine integrating whole-genome sequencing, comprehensive metabolomics, and advanced imaging Hou YC, Yu HC, Martin R 2020-01-24 PMC
Dysregulation of multiple metabolic networks related to brain transmethylation and polyamine pathways in Alzheimer disea... Mahajan UV, Varma VR, Griswold ME 2020-01-24 PMC
Genome-wide scan identifies novel genetic loci regulating salivary metabolite levels Nag A, Kurushima Y, Bowyer RC 2020-01-21 PMC
ERRATUM 2020-01-20 PMC
Dataset on the mass spectrometry-based proteomic profiling of the kidney from wild type and the dystrophic mdx-4cv mouse... Dowling P, Zweyer M, Raucamp M 2020-01-02 PMC
Schwann cell reprogramming and lung cancer progression: a meta-analysis of transcriptome data Silva VM, Gomes JA, Tenório LP 2019-12-31 PMC
LncRNA RP11-422N16.3 Inhibits Cell Proliferation and EMT, and Induces Apoptosis in Hepatocellular Carcinoma Cells by Spo... Sun Y, Zhou Q, Li J 2019-12-12 PMC
Systematic evaluation of differential splicing tools for RNA-seq studies Mehmood A, Laiho A, Venäläinen MS 2019-12-05 PMC
Short-term treatment with a peroxisome proliferator-activated receptor α agonist influences plasma one-carbon metabolite... Lysne V, Bjørndal B, Grinna ML 2019-12-05 PMC
Identification Of Novel lncRNAs For Detection Of HBV-Associated Hepatocellular Carcinoma Li Y, Chen X, Huang H 2019-11-27 PMC
Combined Omics Reveals That Disruption of the Selenocysteine Lyase Gene Affects Amino Acid Pathways in Mice Seale LA, Khadka VS, Menor M 2019-10-26 PMC
Genomic Basis of Convergent Island Phenotypes in Boa Constrictors Card DC, Adams RH, Schield DR 2019-10-23 PMC
Rrm2b deletion causes mitochondrial metabolic defects in renal tubules Chen YF, Lin IH, Guo YR 2019-09-13 PMC
Gene–gene interaction among cell adhesion genes and risk of nonsyndromic cleft lip with or without cleft palate in Chine... Liu D, Wang M, Yuan Y 2019-08-16 PMC
miR-873-5p targets mitochondrial GNMT-Complex II interface contributing to non-alcoholic fatty liver disease Fernández-Tussy P, Fernández-Ramos D, Lo... 2019-08-16 PMC
A Network of SLC and ABC Transporter and DME Genes Involved in Remote Sensing and Signaling in the Gut-Liver-Kidney Axis Rosenthal SB, Bush KT, Nigam SK 2019-08-15 PMC
Genome-wide promoter DNA Methylation Profiling of Hepatocellular Carcinomas Arising Either Spontaneously or due to Chron... Kovi RC, Bhusari S, Mav D 2019-07-05 PMC
The effect of breed and diet type on the global transcriptome of hepatic tissue in beef cattle divergent for feed effici... Higgins MG, Kenny DA, Fitzsimons C 2019-06-26 PMC
Glycine Metabolism and Its Alterations in Obesity and Metabolic Diseases Alves A, Bassot A, Bulteau AL 2019-06-16 PMC
An acyl-CoA dehydrogenase microplate activity assay using recombinant porcine electron transfer flavoprotein Zhang Y, Mohsen AW, Kochersperger C 2019-06-10 PMC
Long noncoding RNA actin filament‐associated protein 1 antisense RNA 1 promotes malignant phenotype through binding with... Yu S, Yang D, Ye Y 2019-05-29 PMC
Analyses of a Panel of Transcripts Identified From a Small Sample Size and Construction of RNA Networks in Hepatocellula... Sheng Z, Wang X, Xu G 2019-05-08 PMC
Accumulation of rare coding variants in genes implicated in risk of human cleft lip with or without cleft palate Marini NJ, Asrani K, Yang W 2019-05-07 PMC
Transcriptome analysis identifies metallothionein as biomarkers to predict recurrence in hepatocellular cacinoma Wang S, Gribskov M 2019-05-06 PMC
Transcriptomic analysis reveals differences in the regulation of amino acid metabolism in asexual and sexual planarians Sekii K, Yorimoto S, Okamoto H 2019-04-16 PMC
Identification of coordinately regulated microRNA-gene networks that differ in baboons discordant for LDL-cholesterol Karere GM, Glenn JP, Birnbaum S 2019-03-15 PMC
Towards precision medicine for stress disorders: diagnostic biomarkers and targeted drugs Le-Niculescu H, Roseberry K, Levey DF 2019-03-12 PMC
Sarcosine is a prostate epigenetic modifier that elicits aberrant methylation patterns through the SAMe‐Dnmts axis Strmiska V, Michalek P, Lackova Z 2019-03-09 PMC
Transcriptomic analyses highlight the likely metabolic consequences of colonization of a cnidarian host by native or non... Lin MF, Takahashi S, Forêt S 2019-02-27 PMC
Transcriptomic analysis reveals protein homeostasis breakdown in the coral Acropora millepora during hypo-saline stress Aguilar C, Raina JB, Fôret S 2019-02-20 PMC
The OMICs Window into Nonalcoholic Fatty Liver Disease (NAFLD) Carulli L, Zanca G, Schepis F 2019-02-01 PMC
Choline‐related‐inherited metabolic diseases—A mini review Wortmann SB, Mayr JA 2019-01-25 PMC
Functional annotation of orthologs in metagenomes: a case study of genes for the transformation of oceanic dimethylsulfo... González JM, Hernández L, Manzano I 2019-01-14 PMC
Effects of PKM2 on global metabolic changes and prognosis in hepatocellular carcinoma: from gene expression to drug disc... Lv WW, Liu D, Liu XC 2018-11-21 PMC
Gene expression profile of muscle adaptation to high-intensity intermittent exercise training in young men Miyamoto-Mikami E, Tsuji K, Horii N 2018-11-14 PMC
标题 作者 日期 链接
Controversials of Microscopic Colitis Mihaly E, Patai Á, Tulassay Z 2021-10-12 PMC
Gut and Brain: Investigating Physiological and Pathological Interactions Between Microbiota and Brain to Gain New Therap... Deidda G, Biazzo M 2021-10-12 PMC
Salivary Interleukin-6 and C-Reactive Protein/Mean Platelet Volume Ratio in the Diagnosis of Late-Onset Neonatal Pneumon... Omran A, Ali Y, Abdalla MO 2021-10-18 PMC
Antifungal Treatment Aggravates Sepsis through the Elimination of Intestinal Fungi Sheng B, Chen Y, Sun L 2021-10-18 PMC
Effect of Observation of Shou Hui Tong Bian Capsule (Polygonum Multiflorum and Aloe-Based Herbal Capsule for Cathartic E... Huang S, Xie Y, Huang Z 2021-10-18 PMC
Role of Micro-RNA for Pain After Surgery: Narrative Review of Animal and Human Studies Cata JP, Gorur A, Yuan X PMC
In vitro Prebiotic Effect of Bread-Making Process in Inflammatory Bowel Disease Microbiome Lluansí A, Llirós M, Oliver L 2021-10-11 PMC
Microbiota–Gut–Brain Axis and Epilepsy: A Review on Mechanisms and Potential Therapeutics Ding M, Lang Y, Shu H 2021-10-11 PMC
Intersections between pneumonia, lowered oxygen saturation percentage and immune activation mediate depression, anxiety,... Al-Jassas HK, Al-Hakeim HK, Maes M 2021-10-24 PMC
Intestinal, liver and lipid disorders in genetically obese rats are more efficiently reduced by dietary milk thistle see... Opyd PM, Jurgoński A 2021-10-22 PMC
Efficacy of macrogol 4000 plus electrolytes in bowel preparation for colonoscopy in patients with chronic constipation Ichijima R, Suzuki S, Esaki M 2021-10-19 PMC
Tests for central sensitization in general practice: a Delphi study den Boer C, Terluin B, van der Wouden JC 2021-10-19 PMC
Effects of semi-purified diet on depressive behaviors in aged mice Takahashi E, Ono E 2021-10-12 PMC
Immunohistochemical Study of Adhesion Molecules in Irritable Bowel Syndrome: A Comparison to Inflammatory Bowel Diseases Mitselou A, Grammeniatis V, Varouktsi A 2021-08-30 PMC
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Is Irritable Bowel Syndrome Considered as Comorbidity in Clinical Trials of Physical Therapy Interventions in Fibromyalg... Rodríguez-Castillejo PM, Fernández-de-la... 2021-10-18 PMC
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Microbiomics in Collusion with the Nervous System in Carcinogenesis: Diagnosis, Pathogenesis and Treatment Hull R, Lolas G, Makrogkikas S 2021-10-11 PMC
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标题 作者 日期 链接
Netting Gut Disease: Neutrophil Extracellular Trap in Intestinal Pathology Chen K, Shao LH, Wang F 2021-10-19 PMC
Long-Term Observations of Thickness Changes of Each Retinal Layer following Macular Hole Surgery Tada A, Machida S, Hara Y 2021-10-19 PMC
Oscillospira - a candidate for the next-generation probiotics Yang J, Li Y, Wen Z 2021-10-25 PMC
Fungal lysozyme leverages the gut microbiota to curb DSS-induced colitis Larsen IS, Jensen BA, Bonazzi E 2021-10-25 PMC
Necrotizing Enterocolitis: LPS/TLR4-Induced Crosstalk Between Canonical TGF-β/Wnt/β-Catenin Pathways and PPARγ Gomart A, Vallée A, Lecarpentier Y 2021-10-12 PMC
CANCER PREVENTION IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE Cleveland NK, Rubin DT PMC
A signature based on 11 autophagy genes for prognosis prediction of colorectal cancer Chen S, Wang Y, Wang B 2021-10-26 PMC
Elective Surgery for Diverticulitis in Swiss Hospitals Faes S, Hübner M, Demartines N 2021-10-12 PMC
Altered Cytokine Endotoxin Responses in Neonatal Encephalopathy Predict MRI Outcomes O'Dea MI, Kelly LA, McKenna E 2021-10-12 PMC
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Lactobacillus reuteri Alleviates Gastrointestinal Toxicity of Rituximab by Regulating the Proinflammatory T Cells in viv... Zhao B, Zhou B, Dong C 2021-10-12 PMC
Fecal Microbiota Transplantation Modulates Renal Phenotype in the Humanized Mouse Model of IgA Nephropathy Lauriero G, Abbad L, Vacca M 2021-10-12 PMC
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Recent Metabolic Advances for Preventing and Treating Acute and Chronic Graft Versus Host Disease Mohamed FA, Thangavelu G, Rhee SY 2021-10-12 PMC
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Omics community detection using multi-resolution clustering Rahnavard A, Chatterjee S, Sayoldin B 2021-05-11 PMC
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A Preliminary Study on the Feasibility of the Quantitative Parameters of Dual-Energy Computed Tomography Enterography in... Xiao WX, Zhu YT, Zhang ZC 2021-10-21 PMC
Irisin attenuates inflammation in a mouse model of ulcerative colitis by altering the intestinal microbiota Huangfu LX, Cai XT, Yang JN 2021-10-11 PMC
Transition of lymphocyte subsets in peritoneal dialysis effluent and its relationship to peritoneal damage Ohashi A, Yamanishi A, Kondo M 2021-10-01 PMC
A dynamic mucin mRNA signature associates with COVID-19 disease presentation and severity Smet A, Breugelmans T, Michiels J 2021-10-08 PMC
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Paclitaxel: Application in Modern Oncology and Nanomedicine-Based Cancer Therapy Sharifi-Rad J, Quispe C, Patra JK 2021-10-18 PMC
Antifungal Treatment Aggravates Sepsis through the Elimination of Intestinal Fungi Sheng B, Chen Y, Sun L 2021-10-18 PMC
Mycoplasma genitalium and M. pneumoniae Regulate a Distinct Set of Protein-Coding Genes in Epithelial Cells Ramos EI, Das K, Harrison AL 2021-10-11 PMC
Vitamins are Indeed Vital Amines: A Discussion of 3 Deficiencies With Neurologic Manifestations Tarhan B, Rahman S, Joseph N 2021-10-23 PMC
Evolving Medical Imaging Techniques for the Assessment of Delayed Graft Function: A Narrative Review Hysi E, Kaur H, Young A 2021-10-21 PMC
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Validation Assessment of a Pain Interference Questionnaire among Student Pharmacists Whaley M, Awad NB, Warholak T 2021-10-15 PMC
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In Vitro Evaluation of a Composite Gelatin–Hyaluronic Acid–Alginate Porous Scaffold with Different Pore Distributions fo... Haung SM, Lin YT, Liu SM 2021-10-09 PMC
Estrogen Receptors in Colorectal Cancer: Facts, Novelties and Perspectives Ditonno I, Losurdo G, Rendina M 2021-10-20 PMC
Connecting the World of Healthcare Virtually: A Scoping Review on Virtual Care Delivery Li C(, Borycki EM, Kushniruk AW 2021-10-05 PMC
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Landscape of Myeloid-derived Suppressor Cell in Tumor Immunotherapy Hao Z, Li R, Wang Y 2021-10-24 PMC
Machine learning for prediction of intra-abdominal abscesses in patients with Crohn’s disease visiting the emergency dep... Levartovsky A, Barash Y, Ben-Horin S 2021-10-22 PMC
Adverse childhood experiences predict reaction to multiple sclerosis diagnosis Eilam-Stock T, Links J, Khan NZ 2021-10-21 PMC
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Role of Micro-RNA for Pain After Surgery: Narrative Review of Animal and Human Studies Cata JP, Gorur A, Yuan X PMC
Immunomodulation in the critically ill Webster NR, Galley HF PMC
In vitro Prebiotic Effect of Bread-Making Process in Inflammatory Bowel Disease Microbiome Lluansí A, Llirós M, Oliver L 2021-10-11 PMC
Integrated Metagenomics and Metabolomics to Reveal the Effects of Policosanol on Modulating the Gut Microbiota and Lipid... Zhai Z, Liu J, Niu KM 2021-10-11 PMC
Microbiome Profiling Using Shotgun Metagenomic Sequencing Identified Unique Microorganisms in COVID-19 Patients With Alt... Li S, Yang S, Zhou Y 2021-10-11 PMC
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p38 MAP Kinase Signaling in Microglia Plays a Sex-Specific Protective Role in CNS Autoimmunity and Regulates Microglial ... McGill MM, Richman AR, Boyd JR 2021-10-11 PMC
An intercrypt subpopulation of goblet cells is essential for colonic mucus barrier function Nyström EE, Martinez-Abad B, Arike L 2021-04-16 PMC
New Insights on CD8+ T Cells in Inflammatory Bowel Disease and Therapeutic Approaches Casalegno Garduño R, Däbritz J 2021-10-11 PMC
NLRP3 Inflammasome: Checkpoint Connecting Innate and Adaptive Immunity in Autoimmune Diseases Zhang Y, Yang W, Li W 2021-10-11 PMC
The COVID-19 Vaccination Hesitancy Among the People With Inflammatory Bowel Disease in China: A Questionnaire Study Wu X, Lin J, Buch H 2021-10-11 PMC
Emerging Evidence on the Effects of Dietary Factors on the Gut Microbiome in Colorectal Cancer Appunni S, Rubens M, Ramamoorthy V 2021-10-11 PMC
Microbiota–Gut–Brain Axis and Epilepsy: A Review on Mechanisms and Potential Therapeutics Ding M, Lang Y, Shu H 2021-10-11 PMC
Tnfaip6 Secreted by Bone Marrow–Derived Mesenchymal Stem Cells Attenuates TNBS-Induced Colitis by Modulating Follicular ... Gu G, Lv X, Liu G 2021-10-11 PMC
Immunoglobulin A nephropathy in a patient with neurofibromatosis type 1: A case report and literature review Rhee H, Kim S, Lee W 2021-10-22 PMC
The incidence of psoriasis among smokers and/or former smokers inflammatory bowel diseases patients treated with tumor n... Yang M, Liu W, Deng Q 2021-10-22 PMC
Application of the neutrophil to lymphocyte ratio in the diagnosis and activity determination of ulcerative colitis: A m... Ma L, Pang X, Ji G 2021-10-22 PMC
End stage liver disease etiology & transplantation referral outcomes of major ethnic groups in British Columbia, Canada:... Chahal D, Marquez V, Hussaini T 2021-10-22 PMC
Intersections between pneumonia, lowered oxygen saturation percentage and immune activation mediate depression, anxiety,... Al-Jassas HK, Al-Hakeim HK, Maes M 2021-10-24 PMC
Frailty but not sarcopenia nor malnutrition increases the risk of developing COVID-19 in older community-dwelling adults Lengelé L, Locquet M, Moutschen M 2021-10-23 PMC
A Rare Dual Diagnosis of Duodenal and Biliary Atresia in a Premature Infant Hess A, Zino C, Camps J 2021-09-23 PMC
Clinicopathological features and prognostic significance of C5aR in human solid tumors: a Meta-analysis Wang Z, Yu W, Qiang Y 2021-10-23 PMC
Continent ileostomy: short- and long-term outcomes of a forgotten procedure Ecker NK, Möslein G, Ecker KW 2021-10-23 PMC
Intestinal, liver and lipid disorders in genetically obese rats are more efficiently reduced by dietary milk thistle see... Opyd PM, Jurgoński A 2021-10-22 PMC
Medical Devices Made of Substances: Possible Innovation and Opportunities for Complex Natural Products Bilia AR, Corazziari ES, Govoni S 2021-08-06 PMC
Stimulation of hypothalamic oxytocin neurons suppresses colorectal cancer progression in mice Pan S, Yin K, Tang Z 2021-09-16 PMC
Surgical placement of customized abdominal vagus nerve stimulating and gastrointestinal serosal surface recording electr... Horn CC, Wong L, Shepard BS 2021-10-22 PMC
Expanding the Phenotypic Spectrum of GPI Anchoring Deficiency Due to Biallelic Variants in GPAA1 Castle AM, Salian S, Bassan H 2021-10-21 PMC
New insight into the features of Behçet’s disease with gastrointestinal ulcer: a cross-sectional observational study Ye JF, Hou CC, Bao HF 2021-10-21 PMC
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Clinical verification of body mass index and tumor immune response in patients with breast cancer receiving preoperative... Takada K, Kashiwagi S, Asano Y 2021-10-20 PMC
Medication Belief is Associated with Improved Adherence to Exclusive Enteral Nutrition in Patients with Crohn’s Disease Li S, Li P, Sun H 2021-10-16 PMC
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Risk and characteristics of tuberculosis after anti-tumor necrosis factor therapy for inflammatory bowel disease: a hosp... Lee JY, Oh K, Hong HS 2021-10-20 PMC
Efficacy of macrogol 4000 plus electrolytes in bowel preparation for colonoscopy in patients with chronic constipation Ichijima R, Suzuki S, Esaki M 2021-10-19 PMC
Tests for central sensitization in general practice: a Delphi study den Boer C, Terluin B, van der Wouden JC 2021-10-19 PMC
Aberrant gut-microbiota-immune-brain axis development in premature neonates with brain damage Seki D, Mayer M, Hausmann B 2021-10-13 PMC
Laparoscopic fenestration and omentopexy as treatment for large splenic pseudocyst: Case report Zafirovikj E, Krsteska B 2021-10-07 PMC
Amyand's hernia- outcome of nylon darn repairs after complicated appendix surgeries in a district hospital: case series Ali MA, Hagbevor I, Kyei MY 2021-10-16 PMC
A Retrospective Study on Chronic Pelvic Pain Treated with Traditional Chinese Medicine Combined Therapy: 179 Cases (2016... Guo S, Chen Y, Tang Q 2021-10-14 PMC
Triptolide is a Promising Therapeutic Approach in Treating Thyroid Cancer Based on in silico and in vitro Experiment Wang F, An SJ, Yin Y 2021-10-11 PMC
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miR-30a-5p inhibits osteogenesis and promotes periodontitis by targeting Runx2 Liu X, Yang B, Zhang Y 2021-10-11 PMC
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The risk of tuberculosis infection in 410 Saudipatients receiving adalimumab therapy Al-Sohaim A, Bawazir AS, Al-Turki T 2021-10-07 PMC
Immunohistochemical Study of Adhesion Molecules in Irritable Bowel Syndrome: A Comparison to Inflammatory Bowel Diseases Mitselou A, Grammeniatis V, Varouktsi A 2021-08-30 PMC
Objective and Personalized Assessment of Disease-Related Knowledge Among Patients With Congenital Heart Disease ― Develo... Akiyama N, Ochiai R, Hokosaki T 2021-09-08 PMC
Diagnostic performance of 18F-fluorodeoxyglucose positron emission tomography/computed tomography in anorectal melanoma Bakare AN, Agrawal A, Saklani A 2021-08-20 PMC
Unusual Presentation of Relapsing Polychondritis in a Patient with Human Immunodeficiency Virus and Reactive Arthritis Alfraji N, Alpert DR 2021-09-28 PMC
Hereditary angio-oedema as a rare cause of small-bowel obstruction Jamil B, Naeem MS, Anachebe T 2019-10-25 PMC

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www.rarefundingteam.com

寻医问药

Findacure是一个组织,其目标是为罕见病患者支持团体提供指导、培训和建议,使这些团体能够有效地工作,以实现我们的共同目标:使罕见病患者得到倾听,并使他们能够获得诊断和治疗。

www.findacure.org.uk

其他组织

如果其他组织想与我们建立伙伴关系,请 让我们知道 ...

关于我们

我们是一个非营利性的病人团体,有很多成员自己也在与IMBS作斗争。

在可能的情况下,我们努力推动对IMBS的总体研究,我们也尽可能地支持个别病人。

域名所有者并对内容负责。Danny Kunz

地址。 丹尼-昆兹 Heilbronnerstr.16/2 71634路德维希堡 德国

电子邮件。 contact@imbs-alliance.org (围绕域名和内容的法律问题) support@imbs-alliance.org (患者支持)

电话。 +49 151 565 273 00(请使用此电话联系,仅用于围绕域名和内容的法律问题,我们目前无法为患者提供电话支持。

外部链接。 即使对其他网站的外部链接进行了仔细调查,我们也不会对外部网站的全部内容的任何部分承担任何责任。

可以下载隐私政策 这里 以PDF格式。

作为替代方案,隐私政策以简单的文本格式提供 这里 .

要查看PDF格式的文件,可使用Acrobat PDF Reader,该软件可下载。 这里 .

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